Our Research
Reliable and high-throughput humanised & personalised models
Human Brain-on-chip and brain organoid for viral infection study
Aim: Utilise lab-grown mini-brain model to investigate virus-host interaction in human context
Research focus: Working on human brain organoid generation and screening the diverse virus (neurotropic vs. other organ-specific virus vs. systemic), analyse the viral infection behavior of neurons
Brain-body organoid-on-chip
Aim: Develop microfluidic device design for brain organoid to multi-organ crosstalk
Research focus: Focusing on new microfluidic device fabrication to cultivate 3D organoids including brain, gut, pancreas, lung, kidney, liver to reveal multi-organ level communications (on-going biological study includes pathogenic infection driven cellular aging and rejuvenate strategy)
Brain inter-regional communications and neural circuits
Aim: Investigate diverse regions of brain organoids and their neural plasticity
Research focus: Focusing on the different regions of 3D brain organoid generation and their communications in cell to organ level, especially focusing on the neural circuits and plasticity
Extracellular Matrix (ECM) and 3D Brain development
Aim: Investigate diverse types of ECM hydrogel and brain develop in tissue scale
Research focus: Focusing on the bioprinting and material technology to apply on 3D brain organoid generation and investigate ECM-cell interaction & morphological stimulations on brain embryogenesis
High-throughput drug screening platform as humanised pre-clinical model
Aim: Develop gradient & high-throughput chips for drug screening utilizing brain organoids
Research focus: Focusing on the design of high-throughput microfluidic chip fabrication for one-stop 3D brain organoid generation and drug screening to screen multiple drug concentration/type
Neuroinflammatory system-on-chip
Aim: Generate a sophisticated neuroinflammation model in brain organoid-on-chip
Research focus: Focusing on new microfluidic device fabrication (µm-mm-cm size) to generate neuroinflammatory cells (microglial, astrocyte) in the 3D brain organoid surrounding to monitor the pathogenic condition (e.g., dementia, traumatic brain injury, stroke-thrombosis) driven neuroinflammation and following impacts on the neurons & neuronal network