Make it HAPPEN & MEANINGFUL

We will create a near-complete model of the human brain and explore its value for personalized therapy

Publications by year

2024

Human Brain In Vitro Model for Pathogen Infection-Related Neurodegeneration Study

Yuwei Yan, Ann-Na Cho
International Journal of Molecular Sciences 25 (12), 6522

Cerebrospinal fluid proteome profiling using machine learning shows a unique protein signature associated with APOE4 genotype

Artur Shvetcov, Shannon Thomson, Ann-Na Cho, Heather M Wilkins, Joanne H Reed, Russell H Swerdlow, David A Brown, Alzheimer's Disease Neuroimaging Initiative, Caitlin A Finney
bioRxiv, 2024.04. 18.590160

2023

Composition for culturing brain organoid based on decellularized brain matrix and method for preparing same

Seung Woo Cho, Ann Na Cho, Jung Seung Lee, Yoonhee Jin
US Patent App. 18/347,142

Blood-Based Transcriptomic Biomarkers Are Predictive of Neurodegeneration Rather Than Alzheimer’s Disease

Artur Shvetcov, Shannon Thomson, Jessica Spathos, Ann-Na Cho, Heather M Wilkins, Shea J Andrews, Fabien Delerue, Timothy A Couttas, Jasmeen Kaur Issar, Finula Isik, Simranpreet Kaur, Eleanor Drummond, Carol Dobson-Stone, Shantel L Duffy, Natasha M Rogers, Daniel Catchpoole, Wendy A Gold, Russell H Swerdlow, David A Brown, Caitlin A Finney
International journal of molecular sciences 24 (19), 15011

Highly efficient organoid culture device and system

Seung Woo Cho, Jin Kim, Yoonhee Jin, Ann Na Cho
US Patent 11,725,173

3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay

Yingqi Zhang, Fengtao Jiang, Yunduo Charles Zhao, Ann-Na Cho, Guocheng Fang, Charles D Cox, Hala Zreiqat, Zu Fu Lu, Hongxu Lu, Lining Arnold Ju
Biomedical Materials 18, 055008

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

Ramón Martínez-Mármol, Rosina Giordano-Santini, Eva Kaulich, Ann-Na Cho, Magdalena Przybyla, Md Asrafuzzaman Riyadh, Emilija Robinson, Keng Yih Chew, Rumelo Amor, Frédéric A Meunier, Giuseppe Balistreri, Kirsty R Short, Yazi D Ke, Lars M Ittner, Massimo A Hilliard
Science Advances 9 (23), eadg2248

Novel Movable Typing for Personalized Vein-Chips in Large Scale: Recapitulate Patient-Specific Virchow's Triad and its Contribution to Cerebral Venous Sinus Thrombosis

Yunduo Charles Zhao, Yingqi Zhang, Zihao Wang, Fengtao Jiang, Kiarash Kyanian, San-Seint-Seint Aye, Tianbo Hong, Parham Vatankhah, Arian Nasser, Allan Sun, Laura Moldovan, Qian P. Su, Ann-Na Cho, Yao Wang, Freda Passam, Timothy Ang, Lining Arnold Ju
Advanced Functional Materials 33, 2214179

2022

Efficient gene expression in human stem cell derived-cortical organoids using adeno associated virus

Ann-Na Cho, Fiona Bright, Nicolle Morey, Carol Au, Lars M Ittner, Yazi D Ke
Cells 11 (20), 3194

2021

The SARS-CoV-2 spike (S) and the orthoreovirus p15 cause neuronal and glial fusion

Ramon Martinez-Marmol, Rosina Giordano-Santini, Eva Kaulich, Ann-Na Cho, Md Asrafuzzaman Riyadh, Emilija Robinson, Giuseppe Balistreri, Frédéric A Meunier, Yazi D Ke, Lars M Ittner, Massimo A Hilliard
BioRxiv, 2021.09. 01.458544

Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

Ann-Na Cho, Yoonhee Jin, Yeonjoo An, Jin Kim, Yi Sun Choi, Jung Seung Lee, Junghoon Kim, Won-Young Choi, Dong-Jun Koo, Weonjin Yu, Gyeong-Eon Chang, Dong-Yoon Kim, Sung-Hyun Jo, Jihun Kim, Sung-Yon Kim, Yun-Gon Kim, Ju Young Kim, Nakwon Choi, Eunji Cheong, Young-Joon Kim, Hyunsoo Shawn Je, Hoon-Chul Kang, Seung-Woo Cho
Nature Communications 12 (1), 4730

2020

NEUROD1 intrinsically initiates differentiation of induced pluripotent stem cells into neural progenitor cells

Won-Young Choi, Ji-Hyun Hwang, Ann-Na Cho, Andrew J Lee, Inkyung Jung, Seung-Woo Cho, Lark Kyun Kim, Young-Joon Kim
Molecules and cells 43 (12), 1011-1022

DNA methylation of Intragenic CpG islands are required for differentiation from iPSC to NPC

Won-Young Choi, Ji-Hyun Hwang, Ann-Na Cho, Andrew J Lee, Jungwoo Lee, Inkyung Jung, Seung-Woo Cho, Lark Kyun Kim, Young-Joon Kim
Stem Cell Reviews and Reports 16, 1316-1327

Chromatin interaction changes during the ipsc-npc model to facilitate the study of biologically significant genes involved in differentiation

Won-Young Choi, Ji-Hyun Hwang, Jin-Young Lee, Ann-Na Cho, Andrew J Lee, Inkyung Jung, Seung-Woo Cho, Lark Kyun Kim, Young-Joon Kim
Genes 11 (10), 1176

2019

Composition for culturing brain organoid based on decellularized brain matrix and method for preparing same

Seung Woo Cho, Ann Na Cho, Jung Seung Lee, Yoonhee Jin
US Patent App. 16/448,954

Magnetic control of axon navigation in reprogrammed neurons

Yoonhee Jin, Jung-uk Lee, Eunna Chung, Kisuk Yang, Jin Kim, Ji-wook Kim, Jong Seung Lee, Ann-Na Cho, Taekyu Oh, Jae-Hyun Lee, Seung-Woo Cho, Jinwoo Cheon
Nano letters 19 (9), 6517-6523

Endothelial-neurosphere crosstalk in microwell arrays regulates self-renewal and differentiation of human neural stem cells

Kisuk Yang, Jong Seung Lee, Sewoon Han, Yoonhee Jin, Ann-Na Cho, Gyeong-Eon Chang, Eunji Cheong, Ji Hun Yang, Seok Chung, Seung-Woo Cho
Journal of Industrial and Engineering Chemistry 74, 148-157

Aligned brain extracellular matrix promotes differentiation and myelination of human-induced pluripotent stem cell-derived oligodendrocytes

Ann-Na Cho, Yoonhee Jin, Suran Kim, Sajeesh Kumar, Heungsoo Shin, Hoon-Chul Kang, Seung-Woo Cho
ACS applied materials & interfaces 11 (17), 15344-15353

Organoids for advanced therapeutics and disease models

Suran Kim, Ann‐Na Cho, Sungjin Min, Sooyeon Kim, Seung‐Woo Cho
Advanced Therapeutics 2 (1), 1800087

2018

Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

Yoonhee Jin, Jung Seung Lee, Jin Kim, Sungjin Min, Soohyun Wi, Ji Hea Yu, Gyeong-Eon Chang, Ann-Na Cho, Yeeun Choi, Da-Hee Ahn, Sung-Rae Cho, Eunji Cheong, Yun-Gon Kim, Hyong-Pyo Kim, Yonghwan Kim, Dong Seok Kim, Hyun Woo Kim, Zhejiu Quan, Hoon-Chul Kang, Seung-Woo Cho
Nature biomedical engineering 2 (7), 522-539

Ferritin nanoparticles for improved self-renewal and differentiation of human neural stem cells

Jung Seung Lee, Kisuk Yang, Ann-Na Cho, Seung-Woo Cho
Biomaterials Research 22 (1), 5

DNA-mediated self-assembly of taste cells and neurons for taste signal transmission

Junsu Yun, Ann-Na Cho, Seung-Woo Cho, Yoon Sung Nam
Biomaterials science 6 (12), 3388-3396

Bio-artificial tongue with tongue extracellular matrix and primary taste cells

Jung Seung Lee, Ann-Na Cho, Yoonhee Jin, Jin Kim, Suran Kim, Seung-Woo Cho
Biomaterials 151, 24-37

2017

Three-dimensional electroconductive hyaluronic acid hydrogels incorporated with carbon nanotubes and polypyrrole by catechol-mediated dispersion enhance neurogenesis of human neural stem cells

Jisoo Shin, Eun Jung Choi, Jung Ho Cho, Ann-Na Cho, Yoonhee Jin, Kisuk Yang, Changsik Song, Seung-Woo Cho
Biomacromolecules 18 (10), 3060-3072

2016

Galactosylated lipidoid nanoparticles for delivery of small interfering RNA to inhibit hepatitis C viral replication in vivo

Hyun‐Ji Park, Eun Je Jeon, Jung Seung Lee, Sang Hyeon Hong, Ann‐Na Cho, Joan Lee, Jae‐Su Moon, Kyeong‐Eun Jung, Jong‐Won Oh, Haeshin Lee, Seung‐Woo Cho
Advanced healthcare materials 5 (22), 2931-2941

Photoactivation of noncovalently assembled peptide ligands on carbon nanotubes enables the dynamic regulation of stem cell differentiation

Hee-Won Kim, Kisuk Yang, Woo-Jin Jeong, Sung-Ju Choi, Jong Seung Lee, Ann-Na Cho, Gyeong-Eon Chang, Eunji Cheong, Seung-Woo Cho, Yong-Beom Lim
ACS applied materials & interfaces 8 (40), 26470-26481

2015

Thermo-responsive polymeric nanoparticles for enhancing neuronal differentiation of human induced pluripotent stem cells

Hye In Seo, Ann-Na Cho, Jiho Jang, Dong-Wook Kim, Seung-Woo Cho, Bong Geun Chung
Nanomedicine: Nanotechnology, Biology and Medicine 11 (7), 1861-1869

2014

Paper-based bioactive scaffolds for stem cell-mediated bone tissue engineering

Hyun-Ji Park, Seung Jung Yu, Kisuk Yang, Yoonhee Jin, Ann-Na Cho, Jin Kim, Bora Lee, Hee Seok Yang, Sung Gap Im, Seung-Woo Cho
Biomaterials 35 (37), 9811-9823